Información de la droga para Sandostatin LAR Depot (octreotide acetate for injectable suspension) (Novartis Pharmaceuticals Corporation): 11  DESCRIPTION

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  • Octreotide is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is known chemically as L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1- (hydroxy-methyl) propyl]-, cyclic (2?7)-disulfide; [R-(R*,R*)].

    Sandostatin LAR Depot is available in a vial containing the sterile drug product, which when mixed with diluent, becomes a suspension that is given as a monthly intragluteal injection. The octreotide is uniformly distributed within the microspheres which are made of a biodegradable glucose star polymer, D,L-lactic and glycolic acids copolymer. Sterile mannitol is added to the microspheres to improve suspendability.

    Sandostatin LAR Depot is available as: sterile 5-mL vials in 3 strengths delivering 10 mg, 20 mg, or 30 mg octreotide-free peptide. Each vial of Sandostatin LAR Depot delivers:

    Name of Ingredient10 mg20 mg30 mg
    octreotide acetate11.2 mg*22.4 mg*33.6 mg*
    D, L-lactic and glycolic acids copolymer188.8 mg377.6 mg566.4 mg
    mannitol41.0 mg81.9 mg122.9 mg

    *Equivalent to 10/20/30 mg octreotide base.

    Each syringe of diluent contains:
    carboxymethylcellulose sodium12.5 mg
    mannitol15.0 mg
    water for injection2.5 mL

    The molecular weight of octreotide is 1019.3 (free peptide, C49H66N10O10S2) and its amino acid sequence is

  • Drug Information Provided by National Library of Medicine (NLM).
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