Información de la droga para Enalapril Maleate Tablets, USP (Sandoz Inc.): Hypertension

  • Administration of enalapril to patients with hypertension of severity ranging from mild to severe results in a reduction of both supine and standing blood pressure usually with no orthostatic component. Symptomatic postural hypotension is therefore infrequent, although it might be anticipated in volume-depleted patients.

    (See WARNINGS.)

    In most patients studied, after oral administration of a single dose of enalapril, onset of antihypertensive activity was seen at one hour with peak reduction of blood pressure achieved by four to six hours.

    At recommended doses, antihypertensive effects have been maintained for atleast 24 hours. In some patients the effects may diminish toward the end of the dosing interval (see DOSAGE AND ADMINISTRATION).

    In some patients achievement of optimal blood pressure reduction may require several weeks of therapy.

    The antihypertensive effects of enalapril have continued during long term therapy. Abrupt withdrawal of enalapril has not been associated with a rapid increase in blood pressure.

    In hemodynamic studies in patients with essential hypertension, blood pressure

    reduction was accompanied by a reduction in peripheral arterial resistance with

    an increase in cardiac output and little or no change in heart rate. Following administration of enalapril, there is an increase in renal blood flow; glomerular filtration rate is usually unchanged. The effects appear to be similar in patients with renovascular hypertension.

    When given together with thiazide-type diuretics, the blood pressure lowering effects of enalapril are approximately additive.

    In a clinical pharmacology study, indomethacin or sulindac was administered to hypertensive patients receiving enalapril. In this study there was no evidence of a blunting of the antihypertensive action of enalapril.

  • Drug Information Provided by National Library of Medicine (NLM).