Información de la droga para DEPO-MEDROL methylprednisolone acetate injectable suspension, USP (Pharmacia and Upjohn Company): DESCRIPTION

  • DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue or intralesional injection. It is available as single-dose vials in two strengths: 40 mg/mL; 80 mg/mL.

    Each mL of these preparations contains:

    Methylprednisolone acetate40 mg80 mg
    Polyethylene glycol 335029 mg28 mg
    Myristyl-gamma-picolinium chloride0.195 mg0.189 mg

    Sodium Chloride was added to adjust tonicity.

    When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.

    The pH of the finished product remains within the USP specified range; e.g., 3.5 to 7.0.

    The chemical name for methylprednisolone acetate is pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-,(6a,11ß)-and the molecular weight is 416.51. The structural formula is represented below:

    DEPO-MEDROL Sterile Aqueous Suspension contains methylprednisolone acetate which is the 6-methyl derivative of prednisolone. Methylprednisolone acetate is a white or practically white, odorless, crystalline powder which melts at about 215° with some decomposition. It is soluble in dioxane, sparingly soluble in acetone, alcohol, chloroform, and methanol, and slightly soluble in ether. It is practically insoluble in water.

  • Drug Information Provided by National Library of Medicine (NLM).