Información de la droga para DEPO-MEDROL methylprednisolone acetate injectable suspension, USP (Pharmacia and Upjohn Company): DESCRIPTION

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  • DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL; 40 mg/mL; 80 mg/mL.

    Each mL of these preparations contains:

    Methylprednisolone acetate..................................20 mg40 mg80 mg
    Polyethylene glycol 3350....................................29.5 mg29.1 mg28.2 mg
    Polysorbate 80 ....................................................1.97 mg1.94 mg1.88 mg
    Monobasic sodium phosphate ..............................6.9 mg6.8 mg6.59 mg
    Dibasic sodium phosphate USP..........................1.44 mg1.42 mg1.37 mg
    Benzyl alcohol added as a preservative................9.3 mg9.16 mg8.88 mg

    Sodium Chloride was added to adjust tonicity.

    When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.

    The pH of the finished product remains within the USP specified range; e.g., 3.5 to 7.0.

    The chemical name for methylprednisolone acetate is pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-,(6a,11ß)-and the molecular weight is 416.51. The structural formula is represented below:

    DEPO-MEDROL Sterile Aqueous Suspension contains methylprednisolone acetate which is the 6-methyl derivative of prednisolone. Methylprednisolone acetate is a white or practically white, odorless, crystalline powder which melts at about 215° with some decomposition. It is soluble in dioxane, sparingly soluble in acetone, alcohol, chloroform, and methanol, and slightly soluble in ether. It is practically insoluble in water.

  • Drug Information Provided by National Library of Medicine (NLM).
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