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Información de la droga para DEPO-MEDROL methylprednisolone acetate injectable suspension, USP (Pharmacia and Upjohn Company): DESCRIPTION
- DESCRIPTION
- CLINICAL PHARMACOLOGY
- CONTRAINDICATIONS
- ADVERSE REACTIONS
- OVERDOSAGE
- DOSAGE AND ADMINISTRATION
- HOW SUPPLIED
- PRINCIPAL DISPLAY PANEL - 20 mg Multidose Vial Label
- PRINCIPAL DISPLAY PANEL - 40 mg Multidose Vial Label
- PRINCIPAL DISPLAY PANEL - 80 mg Multidose Vial Label
DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL; 40 mg/mL; 80 mg/mL.
Each mL of these preparations contains:
Methylprednisolone acetate..................................20 mg 40 mg 80 mg Polyethylene glycol 3350....................................29.5 mg 29.1 mg 28.2 mg Polysorbate 80 ....................................................1.97 mg 1.94 mg 1.88 mg Monobasic sodium phosphate ..............................6.9 mg 6.8 mg 6.59 mg Dibasic sodium phosphate USP..........................1.44 mg 1.42 mg 1.37 mg Benzyl alcohol added as a preservative................9.3 mg 9.16 mg 8.88 mg Sodium Chloride was added to adjust tonicity.
When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.
The pH of the finished product remains within the USP specified range; e.g., 3.5 to 7.0.
The chemical name for methylprednisolone acetate is pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-,(6a,11ß)-and the molecular weight is 416.51. The structural formula is represented below:

DEPO-MEDROL Sterile Aqueous Suspension contains methylprednisolone acetate which is the 6-methyl derivative of prednisolone. Methylprednisolone acetate is a white or practically white, odorless, crystalline powder which melts at about 215° with some decomposition. It is soluble in dioxane, sparingly soluble in acetone, alcohol, chloroform, and methanol, and slightly soluble in ether. It is practically insoluble in water.
- Drug Information Provided by National Library of Medicine (NLM).