Información de la droga para CLOTRIMAZOLE AND BETAMETHASONE DIPROPIONATE CREAM USP 1%/0.05% (base) (E. FOUGERA and CO.): DESCRIPTION

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  • Clotrimazole and Betamethasone Dipropionate Cream USP contains combinations of clotrimazole USP, a synthetic antifungal agent, and betamethasone dipropionate USP, a synthetic corticosteroid, for dermatologic use.

    Chemically, clotrimazole is 1-(o-chloro-α,α-diphenylbenzyl) imidazole, with the empirical formula C22H17CIN2, a molecular weight of 344.84, and the following structural formula:

    Clotrimazole is an odorless, white crystalline powder, insoluble in water and soluble in ethanol.

    Betamethasone dipropionate has the chemical name 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate, with the empirical formula C28H37FO7, a molecular weight of 504.59, and the following structural formula:

    Betamethasone dipropionate is a white to creamy white, odorless crystalline powder, insoluble in water.

    Each gram of Clotrimazole and Betamethasone Dipropionate Cream USP, contains 10 mg clotrimazole and 0.64 mg betamethasone dipropionate (equivalent to 0.5 mg betamethasone), in a hydrophilic cream consisting of purified water, mineral oil, white petrolatum, cetearyl alcohol 70/30, ceteareth-30, propylene glycol, sodium phosphate monobasic, and phosphoric acid; benzyl alcohol as a preservative.

    Clotrimazole and Betamethasone Dipropionate Cream USP, is smooth, uniform, and white to off-white in color.

  • Drug Information Provided by National Library of Medicine (NLM).